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ITERATIVE APPROACH

iterative tools

MUSCLE

Multiple Sequence Comparison by Log Expectation

  • This program can achieve both better average accuracy and better speed.

  • MUSCLE uses FASTA format for both input and output.

  • It also offers CLUSTALW, MSF, HTML, Phylip sequential and Phylip interleaved formats for output.

PRALINE

Profile Alignment

  • Integrate information from database homology searches to generate a homology-extended multiple alignment.

  • Can be used through two separate interfaces: one has been designed to cater to more advanced needs of researchers in the field, and the other for standard construction of high confidence alignments.

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mechanism of iterative approach

ADVANTAGES

Can overcome the inherent limitation of  progressive alignment method

Improves  on progressive methods with a more accurate distance measure to assess the relatedness of two sequences

Suitable to align large number of sequences

MSA approaches comparison

Alignment

Functions

Mechanism

Time Taken

Tools

WhatsApp Image 2019-05-22 at 3.18.46 AM.

1.     Muhammad Iqbal Bin Abu Bakar (192113)

2.     Nusyazwan Faiz Bin Nushaimin (194256)

3.     Nurul Farhanah Binti Zul (192160)

4.     Nur Syakirah Binti Mohammad Mahfud (192064)

5.     Nur Syahira Binti Mohd Ariffin (192347)

6.     Nur Syazwani Binti Abdul Haziz (192246)

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